If you have LowB1 and are experiencing numbness, tingling, burning and/or shooting pains in your feet and legs, you may feel improvement within 30 days after taking a high-potency bioactive form of Vitamin B1 as directed.* Improvement in other symptoms associated with LowB1–such as forgetfulness, decreased mental focus, instability when walking, loss of appetite, fatigue, irritability and muscle weakness–generally takes longer.